SGC707, Allosteric PRMT3 Inhibitor


Catalog No. 规格 价格库存数量
S0016-2 2 mg solid ¥129


Biological Activity:

SGC707 is a potent, selective and cell permeable allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 31 nM. It has >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well-characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease.

How to Use:

In vitro: SGC707 was used at 5-10 μM final concentration in various in vitro assays.
In vivo: n/a

1. Kaniskan Hü, et al. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). (2015) Angew Chem Int Ed Engl. In press.


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