详情描述
Abexinostat, also known as PCI-24781 or CRA-024781, is novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis.
Product information
CAS Number: 58-33-3
Molecular Weight: 320.88
Formula: C17H21ClN2S
Synonym:
Diprazin
Romergan
Lergigan
Phenergan
Fellozine
NSC-231688
Chemical Name: dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine hydrochloride
Smiles: Cl.CN(C)C(C)CN1C2=CC=CC=C2SC2=CC=CC=C12
InChiKey: XXPDBLUZJRXNNZ-UHFFFAOYSA-N
InChi: InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.