详情描述
TRV130 is a µ- opioid receptor agonist, that is currently under evaluation in human clinical trials for the treatment of acute severe pain. TRV130 is a functionally selective μ-opioid receptor agonist developed by Trevena Inc. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less β-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine. (http://en.wikipedia.org/wiki/TRV130). Oliceridine is now discontinued since it was recently listed as a controlled substance.
Product information
CAS Number: 1401028-25-8
Molecular Weight: 386.55
Formula: C22H30N2O2S
Synonym:
Oliceridine racemate
TRV-130 Racemate
Chemical Name: [(3-methoxythiophen-2-yl)methyl]({2-[9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine
Smiles: COC1C=CSC=1CNCCC1(CCOC2(C1)CCCC2)C1=CC=CC=N1
InChiKey: DMNOVGJWPASQDL-UHFFFAOYSA-N
InChi: InChI=1S/C22H30N2O2S/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.