详情描述
Tetrodotoxin is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels, blocking nerve and muscle action potentials.
Product information
CAS Number: 4368-28-9
Molecular Weight: 319.27
Formula: C11H17N3O8
Synonym:
TTx
Chemical Name: (1R,5R,6R,7R,9S,11S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1⁷,¹¹.0¹,⁶]tetradec-3-ene-5,9,12,13,14-pentol
Smiles: NC1N[C@]23[C@H]([C@H]4O[C@](O)(O[C@@H](C2O)[C@]4(O)CO)[C@H]3O)[C@@H](O)N=1
InChiKey: CFMYXEVWODSLAX-HUILCFQTSA-N
InChi: InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3?,4-,5+,6-,7+,9+,10-,11+/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Bane V, Lehane M, Dikshit M, O'Riordan A, Furey A. Tetrodotoxin: chemistry, toxicity, source, distribution and detection. Toxins (Basel). 2014 Feb 21;6(2):693-755.
- Lee CH, Ruben PC. Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin. Channels (Austin). 2008 Nov-Dec;2(6):407-12.
Products are for research use only. Not for human use.