详情描述
Azilsartan-d5 is intended for use as an internal standard for the quantification of azilsartan by GC- or LC-MS. Azilsartan is an antagonist of the angiotensin II type 1 receptor and the active metabolite of azilsartan medoxomil. Azilsartan is formed from azilsartan medoxomil by hydrolysis in the gastrointestinal tract and liver. Azilsartan also acts as an inverse agonist, inhibiting angiotensin II-induced accumulation of inositol-1-phosphate in COS-7 cells expressing recombinant human AT1. It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips. Azilsartan inhibits the angiotensin II-induced pressor response in conscious normotensive rats.
Product information
CAS Number: 1346599-45-8
Molecular Weight: 461.48
Formula: C25H20N4O5
Synonym:
TAK-536 D5
Chemical Name: 2-[(1,1,2,2,2-²H₅)ethoxy]-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid
Smiles: [2H]C([2H])([2H])C([2H])([2H])OC1=NC2=CC=CC(C(O)=O)=C2N1CC1C=CC(=CC=1)C1=CC=CC=C1C1NC(=O)ON=1
InChiKey: KGSXMPPBFPAXLY-ZBJDZAJPSA-N
InChi: InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)/i1D3,2D2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.