详情描述
QL47, also known as QL-XII-47, is a potent and selective BTK inhibitor, which covalently modifies Cys481. QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations.
Product information
CAS Number: 1469988-75-7
Molecular Weight: 447.49
Formula: C27H21N5O2
Synonym:
BTK Inhibitor
QL 47
QL-47
Chemical Name: 9-(1-methyl-1H-pyrazol-4-yl)-1-[1-(prop-2-enoyl)-2,3-dihydro-1H-indol-6-yl]-1H,2H-benzo[h]1,6-naphthyridin-2-one
Smiles: CN1C=C(C=N1)C1=CC2=C3C(C=CC(=O)N3C3=CC4=C(CCN4C(=O)C=C)C=C3)=CN=C2C=C1
InChiKey: RTRNJQOBEOISFQ-UHFFFAOYSA-N
InChi: InChI=1S/C27H21N5O2/c1-3-25(33)31-11-10-17-4-7-21(13-24(17)31)32-26(34)9-6-19-14-28-23-8-5-18(12-22(23)27(19)32)20-15-29-30(2)16-20/h3-9,12-16H,1,10-11H2,2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.