详情描述
SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.
Product information
CAS Number: 85375-15-1
Molecular Weight: 371.90
Formula: C22H26ClNO2
Synonym:
SKF89976A HCl
Chemical Name: 1-(4, 4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
Smiles: Cl.OC(=O)C1CN(CCC=C(C2C=CC=CC=2)C2C=CC=CC=2)CCC1
InChiKey: SNGGBKYQZVAQKA-UHFFFAOYSA-N
InChi: InChI=1S/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Schwark, W.S., Löscher, W. Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 329, 367–371 (1985).
Products are for research use only. Not for human use.