详情描述
RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL, DAG lipase) with IC50 of 4 μM for cholinesterase activity. RHC 80267 inhibits cyclooxygenase (COX) activity, phospholipase C (PLC) activity and the hydrolysis of phosphatidylcholine (PC).
Product information
CAS Number: 83654-05-1
Molecular Weight: 394.51
Formula: C20H34N4O4
Synonym:
RHC80267
RHC-80267
U 57908
U57908
Chemical Name: cyclohexylideneamino N-[6-({[(cyclohexylideneamino)oxy]carbonyl}amino)hexyl]carbamate
Smiles: O=C(NCCCCCCNC(=O)ON=C1CCCCC1)ON=C1CCCCC1
InChiKey: RXSVYGIGWRDVQC-UHFFFAOYSA-N
InChi: InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 79 mg/mL (200.25 mM) Ethanol 79 mg/mL (200.25 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Philippe Ghisdal, et al. Eur J Pharmacol. 2005 Jul 4;517(1-2):97-102.
- T D Oglesby, R R Gorman. Biochim Biophys Acta. 1984 Apr 18
Products are for research use only. Not for human use.