Tegatrabetan (BC-2059)

Tegatrabetan (BC2059) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.

Product information

CAS Number: 1227637-23-1

Molecular Weight: 588.74

Formula: C28H36N4O6S2

Chemical Name: (9E,10E)-2,7-bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime

Smiles: C[C@@H]1CN(C[C@H](C)C1)S(=O)(=O)C1C=C2/C(=N\O)/C3C=C(C=CC=3/C(=N\O)/C2=CC=1)S(=O)(=O)N1C[C@H](C)C[C@H](C)C1

InChiKey: GAPRVZKWPDRAJA-TVRZPQSBSA-N

InChi: InChI=1S/C28H36N4O6S2/c1-17-9-18(2)14-31(13-17)39(35,36)21-5-7-23-25(11-21)28(30-34)26-12-22(6-8-24(26)27(23)29-33)40(37,38)32-15-19(3)10-20(4)16-32/h5-8,11-12,17-20,33-34H,9-10,13-16H2,1-4H3/b29-27-,30-28+/t17-,18+,19-,20+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 100 mg/mL (169.85 mM) Water 100 mg/mL (169.85 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. W Fiskus, et al. Leukemia. 2015 Jun;29(6):1267-78.

Products are for research use only. Not for human use.