详情描述
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator that induces apoptosis in NB4 cells via negatively regulating intracellular NO and Zn2+ signaling. TPEN (TPEDA) may be a potential therapeutic strategy for APL (acute promyelocytic leukemia).
Product information
CAS Number: 16858-02-9
Molecular Weight: 424.54
Formula: C26H28N6
Synonym:
TPEDA
Chemical Name: N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine
Smiles: C(C1=CC=CC=N1)N(CC1=CC=CC=N1)CCN(CC1=CC=CC=N1)CC1=CC=CC=N1
InChiKey: CVRXLMUYFMERMJ-UHFFFAOYSA-N
InChi: InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 85 mg/mL (200.22 mM) Ethanol 85 mg/mL (200.22 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Bo Zhu, et al. Cell Physiol Biochem. 2017;42(5):1822-1836.
Products are for research use only. Not for human use.