JNJ-632

JNJ-632 is a potent hepatitis B virus (HBV) capsid assembly modulator (CAM) with mean EC50 of 121 nM in HepG2.2.15 cells.

Product information

CAS Number: 1572510-42-9

Molecular Weight: 378.42

Formula: C18H19FN2O4S

Chemical Name: (S)-N-(4-fluoro-3-methylphenyl)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzamide

Smiles: CC1=CC(=CC=C1F)NC(=O)C1=CC(=CC=C1)S(=O)(=O)N[C@@H]1COCC1

InChiKey: JIZGLOVJKCSHTH-HNNXBMFYSA-N

InChi: InChI=1S/C18H19FN2O4S/c1-12-9-14(5-6-17(12)19)20-18(22)13-3-2-4-16(10-13)26(23,24)21-15-7-8-25-11-15/h2-6,9-10,15,21H,7-8,11H2,1H3,(H,20,22)/t15-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 76 mg/mL (200.84 mM) Ethanol 76 mg/mL (200.84 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Jan Martin Berke, et al. Antimicrob Agents Chemother. 2017 Jul

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