RO495

RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2).

Product information

CAS Number: 1258296-60-4

Molecular Weight: 389.24

Formula: C17H14Cl2N6O

Chemical Name: N-[2-[(2-amino-6-methylpyrimidin-4-yl)amino]pyridin-4-yl]-2,6-dichlorobenzamide

Smiles: CC1=CC(NC2=CC(=CC=N2)NC(=O)C2C(Cl)=CC=CC=2Cl)=NC(N)=N1

InChiKey: LNGDQKGREFSTHB-UHFFFAOYSA-N

InChi: InChI=1S/C17H14Cl2N6O/c1-9-7-14(25-17(20)22-9)24-13-8-10(5-6-21-13)23-16(26)15-11(18)3-2-4-12(15)19/h2-8H,1H3,(H4,20,21,22,23,24,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 78 mg/mL(200.39 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Tobie D Lee, et al. Mol Pharmacol. 2019 Nov;96(5):629-640.

Products are for research use only. Not for human use.