SC-79

SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases. SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head. SC-79 injections inhibited alcohol-induced osteonecrosis. Alcohol-induced ONFH is associated with suppression of p-Akt-Ser473 in the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells.

Product information

CAS Number: 305834-79-1

Molecular Weight: 364.78

Formula: C17H17ClN2O5

Synonym:

SC 79

SC-79

SC79

Chemical Name: ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Smiles: CCOC(=O)C1C(C(C#N)C(=O)OCC)C2=CC(Cl)=CC=C2OC=1N

InChiKey: DXVKFBGVVRSOLI-UHFFFAOYSA-N

InChi: InChI=1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Chen YX, Tao SC, Xu ZL, Yin WJ, Zhang YL, Yin JH, Gao YS, Zhang CQ. Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head. Oncotarget. 2017 May 9;8(19):31065-31078. doi: 10.18632/oncotarget.16075. PubMed PMID: 28415692; PubMed Central PMCID: PMC5458189.
2. Yang W, Yang Y, Xia L, Yang Y, Wang F, Song M, Chen X, Liu J, Song Y, Zhao Y, Yang C. MiR-221 Promotes Capan-2 Pancreatic Ductal Adenocarcinoma Cells Proliferation by Targeting PTEN-Akt. Cell Physiol Biochem. 2016;38(6):2366-74. doi: 10.1159/000445589. Epub 2016 May 27. PubMed PMID: 27230035.
3. Li C, Siragy HM. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E302-10. doi: 10.1152/ajpendo.00603.2014. Epub 2015 Jun 16. PubMed PMID: 26081285; PubMed Central PMCID: PMC4525115.

Products are for research use only. Not for human use.