详情描述
Napabucasin (BBI608) is a potent and selective STAT3 inhibitor. Napabucasin can inhibit gene transcription driven by Stat3 and cancer stemness properties, can inhibit stemness gene expression and block spherogenesis of or kill stemness-high cancer cells isolated from a variety of cancer types (IC50 ~0.14-1.25 µM), but not hematopoietic stem cells. Napabucasin inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice.
Product information
CAS Number: 83280-65-3
Molecular Weight: 240.21
Formula: C14H8O4
Synonym:
BBI608
BBI 608
BB-I608
Napabucasin
Chemical Name: 2-acetylnaphtho[2,3-b]furan-4,9-dione
Smiles: CC(=O)C1=CC2=C(O1)C(=O)C1=CC=CC=C1C2=O
InChiKey: DPHUWDIXHNQOSY-UHFFFAOYSA-N
InChi: InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 20 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
Napabucasin (BBI608) was used at 0.5-2 µM final concentration in various assays.
In Vivo:
Napabucasin (BBI608) can be dosed to mice at 50 mg/Kg by IP injection once per day in xenograft models.
References:
- Li Y, et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. （2015）Proc Natl Acad Sci USA. 112(6):1839-44.
Products are for research use only. Not for human use.