详情描述
Ryuvidine is an inhibitor of SETD8 with cellular activity. It also acts as a CDK4 inhibitor and inducer of the DNA damage response.
Product information
CAS Number: 265312-55-8
Molecular Weight: 284.33
Formula: C15H12N2O2S
Chemical Name: 2-methyl-5-(p-tolylamino)benzo[d]thiazole-4,7-dione
Smiles: CC1C=CC(=CC=1)NC1=CC(=O)C2SC(C)=NC=2C1=O
InChiKey: HFPLHASLIOXVGS-UHFFFAOYSA-N
InChi: InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 20 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
Ryuvidine was used at 10 µM final concentration in various in vitro assays.
References:
- Ryu CK, et al. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. (2000) Bioorg Med Chem Lett. 10(5):461-4.
- Blum G, et al. Small-molecule inhibitors of SETD8 with cellular activity. (2014) ACS Chem Biol. 9(11):2471-8.
Products are for research use only. Not for human use.