Propargyl-PEG2-NHBoc

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Catalog No. Size 价格库存数量
S0040-2 Contact sales@xcessbio.com for quotation ¥100
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S0040-10 Contact sales@xcessbio.com for quotation ¥100
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详情描述

Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 869310-84-9

Molecular Weight: 243.30

Formula: C12H21NO4

Chemical Name: tert-butyl N-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl}carbamate

Smiles: CC(C)(C)OC(=O)NCCOCCOCC#C

InChiKey: WBOOWEAGRWGHMV-UHFFFAOYSA-N

InChi: InChI=1S/C12H21NO4/c1-5-7-15-9-10-16-8-6-13-11(14)17-12(2,3)4/h1H,6-10H2,2-4H3,(H,13,14)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. Nello Mainolfi, et al. rak degraders and uses thereof. US20190192668A1.

Products are for research use only. Not for human use.

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