Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride


Catalog No. Size 价格库存数量
S0105-2 Contact for quotation ¥100
S0105-10 Contact for quotation ¥100


Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

Product information

Molecular Weight: 541.98

Formula: C23H32ClN5O8

Chemical Name: N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)-2-(2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxoisoindolin-4-ylamino)acetamide hydrochloride



InChi: InChI=1S/C23H31N5O8.ClH/c24-6-8-34-10-12-36-13-11-35-9-7-25-19(30)14-26-16-3-1-2-15-20(16)23(33)28(22(15)32)17-4-5-18(29)27-21(17)31;/h1-3,17,26H,4-14,24H2,(H,25,30)(H,27,29,31);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.


  1. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
  2. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Products are for research use only. Not for human use.


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