Br-PEG6-C2-NHBoc

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Catalog No. Size 价格库存数量
S0128-2 Contact sales@xcessbio.com for quotation ¥100
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S0128-10 Contact sales@xcessbio.com for quotation ¥100
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不可用

详情描述

Br-PEG6-C2-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

Molecular Weight: 488.41

Formula: C19H38BrNO8

Chemical Name: tert-butyl N-(20-bromo-3,6,9,12,15,18-hexaoxaicosan-1-yl)carbamate

Smiles: CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCBr

InChiKey: IKFUKQOSGQPPAB-UHFFFAOYSA-N

InChi: InChI=1S/C19H38BrNO8/c1-19(2,3)29-18(22)21-5-7-24-9-11-26-13-15-28-17-16-27-14-12-25-10-8-23-6-4-20/h4-17H2,1-3H3,(H,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Products are for research use only. Not for human use.

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