Isoforskolin

Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis.

Product information

CAS Number: 64657-21-2

Molecular Weight: 410.50

Formula: C22H34O7

Synonym:

Coleonol B

Chemical Name: (3R, 4aR, 5S, 6S, 6aS, 10S, 10aR, 10bS)-3-ethenyl-5, 10, 10b-trihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2, 1-b]pyran-6-yl acetate

Smiles: CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](OC(C)=O)[C@H](O)[C@@]1(C)O[C@](C)(CC(=O)[C@@]12O)C=C

InChiKey: CLOQVZCSBYBUPB-KGGHGJDLSA-N

InChi: InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Isoforskolin downregulates the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA).

References:

1. Zhao H, et al. Isoforskolin downregulates proinflammatory responses induced by Borrelia burgdorferi basic membrane protein A.Exp Ther Med. 2017 Dec;14(6):5974-5980.

Products are for research use only. Not for human use.