D-Trimannuronic acid

D-Trimannuronic acid, an alginate oligomer is extracted from seaweed. D-Trimannuronic acid can induce TNF‐α secretion by mouse macrophage cell lines. D-Trimannuronic acid can be used for the research of pain and vascular dementia.

Product information

CAS Number: 66754-13-0

Molecular Weight: 546.39

Formula: C18H26O19

Chemical Name: (2S, 3S, 4R, 5S, 6R)-3-{[(2R, 3S, 4R, 5S, 6S)-6-carboxy-5-{[(2R, 3S, 4S, 5S, 6S)-6-carboxy-3, 4, 5-trihydroxyoxan-2-yl]oxy}-3, 4-dihydroxyoxan-2-yl]oxy}-4, 5, 6-trihydroxyoxane-2-carboxylic acid

Smiles: O[C@@H]1O[C@@H]([C@@H](O[C@@H]2O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@@H]3O)C(O)=O)[C@H](O)[C@@H]2O)C(O)=O)[C@H](O)[C@@H]1O)C(O)=O

InChiKey: LCLHHZYHLXDRQG-BUOBQAFFSA-N

InChi: InChI=1S/C18H26O19/c19-1-2(20)10(13(26)27)36-17(6(1)24)35-9-4(22)7(25)18(37-12(9)15(30)31)34-8-3(21)5(23)16(32)33-11(8)14(28)29/h1-12,16-25,32H,(H,26,27)(H,28,29)(H,30,31)/t1-,2-,3+,4+,5-,6-,7-,8-,9-,10-,11-,12-,16+,17+,18+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Iwamoto M, et, al. Structure-activity relationship of alginate oligosaccharides in the induction of cytokine production from RAW264.7 cells. FEBS Lett. 2005 Aug 15; 579(20): 4423-9.
2. Geng M, et, al. Application of sodium alginate oligose and derivative to treatment of pain. CN106344595A.
3. Geng M, et, al. Application of sodium alginate oligose and derivative to treatment of vascular dementia. CN106344593A

Products are for research use only. Not for human use.