Butylated hydroxytoluene

Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products. Butylated hydroxytoluene is a Ferroptosis inhibitor.

Product information

CAS Number: 128-37-0

Molecular Weight: 220.35

Formula: C15H24O

Chemical Name: 2, 6-di-tert-butyl-4-methylphenol

Smiles: CC1C=C(C(O)=C(C=1)C(C)(C)C)C(C)(C)C

InChiKey: NLZUEZXRPGMBCV-UHFFFAOYSA-N

InChi: InChI=1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (453.82 mM; Need ultrasonic) H2O : 1 mg/mL (4.54 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Butylhydroxytoluene (BHT) is well-known as a potent promoter of carcinogen-induced lung tumors in mice. Butylated hydroxytoluene (orally; 400 mg/kg; weekly) administration increases the susceptibility of 7-week-old rasH2 mice to lung carcinogens

References:

1. Babich H, et al. Butylated hydroxytoluene (BHT): a review. Environ Res. 1982 Oct;29(1):1-29.
2. Stockwell BR, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. ell. 2017 Oct 5;171(2):273-285.
3. Umemura T, et al. Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis. J Cancer Res Clin Oncol. 2001 Oct;127(10):583-90.

Products are for research use only. Not for human use.