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CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism.

Product information

CAS Number: 256497-58-2

Molecular Weight: 556.40

Formula: C27H26BrNO7



Chemical Name: (2S, 3R, 4R, 5S, 6R)-6-(4-bromophenyl)-2, 3-dihydroxy-N, 10, 12-trimethoxy-5-phenyl-7-oxatricyclo[, ]dodeca-1(12), 8, 10-triene-4-carboxamide

Smiles: COC1=CC(OC)=C2C(=C1)O[C@]1([C@@H]([C@H]([C@@H](O)[C@]12O)C(=O)NOC)C1C=CC=CC=1)C1C=CC(Br)=CC=1


InChi: InChI=1S/C27H26BrNO7/c1-33-18-13-19(34-2)23-20(14-18)36-27(16-9-11-17(28)12-10-16)22(15-7-5-4-6-8-15)21(25(31)29-35-3)24(30)26(23,27)32/h4-14,21-22,24,30,32H,1-3H3,(H,29,31)/t21-,22-,24-,26+,27+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Manier S, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10;9(389). pii: eaal2668.

Products are for research use only. Not for human use.


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