Bax activator-1

Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis.

Product information

CAS Number: 1638526-94-9

Molecular Weight: 488.62

Formula: C29H36N4O3

Chemical Name: (3R)-1-{5-[(3, 4-dimethylphenyl)methyl]-1-[(3-methoxyphenyl)methyl]-1H, 4H, 5H, 6H, 7H-pyrazolo[4, 3-c]pyridine-3-carbonyl}piperidin-3-ol

Smiles: CC1=CC(CN2CC3C(=NN(CC4C=C(C=CC=4)OC)C=3CC2)C(=O)N2C[C@H](O)CCC2)=CC=C1C

InChiKey: OLNVSYZSZXRLCF-XMMPIXPASA-N

InChi: InChI=1S/C29H36N4O3/c1-20-9-10-23(14-21(20)2)16-31-13-11-27-26(19-31)28(29(35)32-12-5-7-24(34)18-32)30-33(27)17-22-6-4-8-25(15-22)36-3/h4,6,8-10,14-15,24,34H,5,7,11-13,16-19H2,1-3H3/t24-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion.

In Vivo:

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice.

References:

1. Zhao G, et al. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Mol Cell Biol. 2014 Apr;34(7):1198-207.

Products are for research use only. Not for human use.