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Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis.

Product information

CAS Number: 1708091-24-0

Molecular Weight: 1108.24

Formula: C58H73N7O15

Chemical Name: (1R)-1-[3-(4-{4-[1-(2-{4-[(2, 4-diaminopyrimidin-5-yl)methyl]-2, 6-dimethoxyphenoxy}ethoxy)ethyl]-2-methoxy-5-nitrophenoxy}butanamido)phenyl]-3-(3, 4-dimethoxyphenyl)propyl (2S)-1-(3, 3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

Smiles: CC(OCCOC1C(=CC(CC2=CN=C(N)N=C2N)=CC=1OC)OC)C1=CC(OC)=C(C=C1[N+]([O-])=O)OCCCC(=O)NC1=CC(=CC=C1)[C@@H](CCC1C=C(OC)C(=CC=1)OC)OC(=O)[C@@H]1CCCCN1C(=O)C(=O)C(C)(C)CC


InChi: InChI=1S/C58H73N7O15/c1-10-58(3,4)53(67)55(68)64-23-12-11-17-42(64)56(69)80-44(21-19-36-20-22-45(72-5)46(28-36)73-6)38-15-13-16-40(31-38)62-51(66)18-14-24-78-48-33-43(65(70)71)41(32-47(48)74-7)35(2)77-25-26-79-52-49(75-8)29-37(30-50(52)76-9)27-39-34-61-57(60)63-54(39)59/h13,15-16,20,22,28-35,42,44H,10-12,14,17-19,21,23-27H2,1-9H3,(H,62,66)(H4,59,60,61,63)/t35?,42-,44+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Gutnick A, et al. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nat Cell Biol. 2019 Jun;21(6):768-777.

Products are for research use only. Not for human use.


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