Catalog No. Size 价格库存数量
S0357-2 2mg solid ¥3,075
S0357-10 10mg solid ¥12,300


Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

Product information

CAS Number: 1135688-15-1

Molecular Weight: 672.81

Formula: C30H49FN6O8S

Chemical Name: methyl (3S)-3-[(2S)-2-[(2S)-2-(6-{5-[(3aS, 4S, 6aR)-2-oxo-hexahydro-1H-thieno[3, 4-d]imidazol-4-yl]pentanamido}hexanamido)-3-methylbutanamido]propanamido]-5-fluoro-4-oxopentanoate

Smiles: CC(C)[C@H](NC(=O)CCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF


InChi: InChI=1S/C30H49FN6O8S/c1-17(2)26(29(43)33-18(3)28(42)34-19(21(38)15-31)14-25(41)45-4)36-24(40)12-6-5-9-13-32-23(39)11-8-7-10-22-27-20(16-46-22)35-30(44)37-27/h17-20,22,26-27H,5-16H2,1-4H3,(H,32,39)(H,33,43)(H,34,42)(H,36,40)(H2,35,37,44)/t18-,19-,20-,22-,26-,27-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Biotin-VAD-FMK is a synthetic peptide designed as a methyl ester to facilitate cell permeability.

In Vivo:

To examine whether caspase-2 is activated in the absence of proteolytic cleavage, an in vivo affinity labeling approach is used, using the biotinylated caspase inhibitor biotin-VAD-fmk that detects only active caspases.


  1. DMSO : ≥ 27.3 mg/mL (40.58 mM)

Products are for research use only. Not for human use.


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