Thonningianin A

Thonningianin A, an ellagitannin, is isolated from the methanolic extract of the African medicinal herb, Thonningia sanguinea. The antioxidant properties of Th A involve radical scavenging, anti-superoxide formation and metal chelation. Anti-cancer activities.

Product information

CAS Number: 271579-11-4

Molecular Weight: 874.71

Formula: C42H34O21

Chemical Name: (10R, 11R, 12R, 13S, 15R)-13-[3, 5-dihydroxy-4-(3-phenylpropanoyl)phenoxy]-3, 4, 5, 12, 21, 22, 23-heptahydroxy-8, 18-dioxo-9, 14, 17-trioxatetracyclo[17.4.0.0, .0, ]tricosa-1(19), 2(7), 3, 5, 20, 22-hexaen-11-yl 3, 4, 5-trihydroxybenzoate

Smiles: O[C@@H]1[C@@H](OC(=O)C2=CC(O)=C(O)C(O)=C2)[C@@H]2OC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(C=C(O)C(O)=C3O)C(=O)OC[C@H]2O[C@H]1OC1C=C(O)C(C(=O)CCC2C=CC=CC=2)=C(O)C=1

InChiKey: XQVKQEFQGYTUAR-VHBRHXFYSA-N

InChi: InChI=1S/C42H34O21/c43-20(7-6-15-4-2-1-3-5-15)30-21(44)10-17(11-22(30)45)60-42-36(55)38(63-39(56)16-8-23(46)31(50)24(47)9-16)37-27(61-42)14-59-40(57)18-12-25(48)32(51)34(53)28(18)29-19(41(58)62-37)13-26(49)33(52)35(29)54/h1-5,8-13,27,36-38,42,44-55H,6-7,14H2/t27-,36-,37-,38-,42-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Thonningianin A effectively inhibited the proliferation of HepG-2 cells by inducing apoptosis, as evidenced by increase in the sub-G1 cell population, DNA fragmentation, and increase in the content of reactive oxygen species.

References:

1. Gyamfi MA, et al. Antioxidant properties of Thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea. Biochem Pharmacol. 2002 May 1;63(9):1725-37.
2. Zhang TT, et al. Effects of thonningianin A in natural foods on apoptosis and cell cycle arrest of HepG-2 human hepatocellular carcinoma cells. Food Funct. 2015 Aug;6(8):2588-97.

Products are for research use only. Not for human use.