Protosappanin B

Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity. Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells.

Product information

CAS Number: 102036-29-3

Molecular Weight: 304.29

Formula: C16H16O6

Synonym:

(-)-Protosappanin B

Chemical Name: (10S)-10-(hydroxymethyl)-8-oxatricyclo[10.4.0.0, ]hexadeca-1(16), 2, 4, 6, 12, 14-hexaene-5, 10, 14, 15-tetrol

Smiles: OC[C@@]1(O)CC2=CC(O)=C(O)C=C2C2=CC=C(O)C=C2OC1

InChiKey: QRTYTQTVJQUCEP-INIZCTEOSA-N

InChi: InChI=1S/C16H16O6/c17-7-16(21)6-9-3-13(19)14(20)5-12(9)11-2-1-10(18)4-15(11)22-8-16/h1-5,17-21H,6-8H2/t16-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (164.32 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Protosappanin B (12.5, 25, 50, 100, 200 µg/mL, 48 hours) dose-dependently inhibits tumor cells, with IC50s of 21.32 µg/mL, 26.73 µg/mL, and 76.53 µg/mL for SW-480, HCT-116, and BTT cells, respectively.

References:

1. Yang X, et al. Antitumor Effects of Purified Protosappanin B Extracted From Lignum Sappan. Integr Cancer Ther. 2016 Mar;15(1):87-95.
2. Yang X, et al. Protosappanin B promotes apoptosis and causes G1 cell cycle arrest in human bladder cancer cells. Sci Rep. 2019 Jan 31;9(1):1048.

Products are for research use only. Not for human use.