Hypocrellin B

Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities.

Product information

CAS Number: 123940-54-5

Molecular Weight: 528.51

Formula: C30H24O9

Chemical Name: 12-acetyl-7, 19-dihydroxy-5, 10, 16, 21-tetramethoxy-13-methylhexacyclo[13.8.0.0, .0, .0, .0, ]tricosa-1(23), 2, 4(22), 5, 7, 10, 12, 15, 18, 20-decaene-9, 17-dione

Smiles: CC(=O)C1C2C3=C4C(CC=1C)=C(OC)C(=O)C1C4=C(C4=C3C(C(=O)C=2OC)=C(O)C=C4OC)C(=CC=1O)OC

InChiKey: APTUSGMALOMQQL-UHFFFAOYSA-N

InChi: InChI=1S/C30H24O9/c1-10-7-12-18-23-19(27(34)29(12)38-5)13(32)8-15(36-3)21(23)22-16(37-4)9-14(33)20-25(22)24(18)26(17(10)11(2)31)30(39-6)28(20)35/h8-9,32-33H,7H2,1-6H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 2 mg/mL (3.78 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Miller GG, et al. Preclinical assessment of hypocrellin B and hypocrellin B derivatives as sensitizers for photodynamic therapy of cancer: progress update. Photochem Photobiol. 1997 Apr;65(4):714-22.
2. Wang X, et al. Hypocrellin B-mediated sonodynamic action induces apoptosis of hepatocellular carcinoma cells. Ultrasonics. 2012 Apr;52(4):543-6.
3. Ma G, et al. Antimicrobial and antileishmanial activities of hypocrellins A and B. Antimicrob Agents Chemother. 2004 Nov;48(11):4450-2.

Products are for research use only. Not for human use.