Ponicidin

Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3.

Product information

CAS Number: 52617-37-5

Molecular Weight: 362.42

Formula: C20H26O6

Synonym:

Rubescensine B

Chemical Name: (2S, 5S, 8R, 9S, 11S, 13S, 14S, 15R, 19S)-13, 14, 19-trihydroxy-16, 16-dimethyl-6-methylidene-10, 12-dioxahexacyclo[9.8.0.0, .0, .0, .0, ]nonadecan-7-one

Smiles: CC1(C)CC[C@H](O)C23[C@@H]1[C@H](O)[C@@]1(O)O[C@@H]2O[C@H]2[C@H]4CC[C@@H]3[C@@]12C(=O)C4=C

InChiKey: WHRDRHNMTIXZNY-AMOJAPPFSA-N

InChi: InChI=1S/C20H26O6/c1-8-9-4-5-10-18-11(21)6-7-17(2,3)12(18)14(23)20(24)19(10,13(8)22)15(9)25-16(18)26-20/h9-12,14-16,21,23-24H,1,4-7H2,2-3H3/t9-,10-,11-,12+,14-,15-,16-,18?,19-,20+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (689.81 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Liu YF, et al. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Int J Mol Sci. 2015 Jan 12;16(1):1576-89.

Products are for research use only. Not for human use.