CFI-400437 HCl, inhibitor of polo-like kinase 4 (PLK4).

CFI-400437 is a potent and selective inhibitor of polo-like kinase 4 (PLK4). The family of Polo-like kinases is important in the regulation of mitotic progression; this work keys on one member, namely Polo-like kinase 4 (PLK4). PLK4 has been identified as a candidate anticancer target which prompted a search for potent and selective inhibitors of PLK4.

Product information

CAS Number: 1247000-76-5

Molecular Weight: 565.49

Formula: C29H30Cl2N6O2

Synonym:

CFI-400437 dihydrochloride

Related CAS Number:

1169211-37-3 (free base)

Chemical Name: (3Z)-5-methoxy-3-({3-[(E)-2-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]ethenyl]-1H-indazol-6-yl}methylidene)-2, 3-dihydro-1H-indol-2-one dihydrochloride

Smiles: Cl.Cl.CN1CCN(CC1)C1=CC=C(C=N1)/C=C/C1=NNC2=CC(/C=C3\C(=O)NC4=CC=C(C=C4\3)OC)=CC=C12

InChiKey: XQZOWXHJNLSRCM-FFJVXDJSSA-N

InChi: InChI=1S/C29H28N6O2.2ClH/c1-34-11-13-35(14-12-34)28-10-5-19(18-30-28)4-8-26-22-7-3-20(16-27(22)33-32-26)15-24-23-17-21(37-2)6-9-25(23)31-29(24)36;;/h3-10,15-18H,11-14H2,1-2H3,(H,31,36)(H,32,33);2*1H/b8-4+,24-15-;;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Suri A , Bailey A W , Tavares M T , et al. Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer[J]. International Journal of Molecular Sciences, 2019, 20(9).

Products are for research use only. Not for human use.