Catalog No. Size 价格库存数量
S0507-2 2mg solid ¥325
S0507-10 10mg solid ¥1,300


CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM.

Product information

CAS Number: 41179-33-3

Molecular Weight: 349.40

Formula: C22H20FNO2

Chemical Name: 4-{2'-fluoro-[1, 1'-biphenyl]-4-yl}-N-(4-hydroxyphenyl)butanamide

Smiles: OC1C=CC(=CC=1)NC(=O)CCCC1C=CC(=CC=1)C1=CC=CC=C1F


InChi: InChI=1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (286.20 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2. CMPD1 induced mitotic arrest and apoptosis in U87 cells. CMPD1 inhibits tubulin polymerisation in glioblastoma cells.


  1. Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.
  2. Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry. 2004 Sep 21;43(37):11658-71.
  3. Phoa AF, et al. Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. Biochem Pharmacol. 2015 Dec 15;98(4):587-601.

Products are for research use only. Not for human use.


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