Salicortin

Salicortin, a phenolic glycoside, has been isolated from many plants such as Populus and Salix species. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Salicortin has anti-amnesic, anti-adipogenic, and immune-modulatory activity.

Product information

CAS Number: 1887055-63-1

Molecular Weight: 424.40

Formula: C20H24O10

Chemical Name: (2-{[(2S, 3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl (1S)-1-hydroxy-6-oxocyclohex-2-ene-1-carboxylate

Smiles: OC[C@H]1O[C@@H](OC2=CC=CC=C2COC(=O)[C@]2(O)C=CCCC2=O)[C@H](O)[C@@H](O)[C@@H]1O

InChiKey: CZDNLUMNELLDDD-JAIJEDJZSA-N

InChi: InChI=1S/C20H24O10/c21-9-13-15(23)16(24)17(25)18(30-13)29-12-6-2-1-5-11(12)10-28-19(26)20(27)8-4-3-7-14(20)22/h1-2,4-6,8,13,15-18,21,23-25,27H,3,7,9-10H2/t13-,15-,16+,17-,18-,20+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Salicortin (100 μM; 2 hours) almost completely retards the phosphorylation of IκBα.

References:

1. Nie S, et al. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Biochem Biophys Res Commun. 2016 Jan 29;470(1):61-67.

Products are for research use only. Not for human use.