Anemarsaponin B

Anemarsaponin B is a steroidal saponin isolated from the rhizomes of A. asphodeloides (Liliaceae). Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect.

Product information

CAS Number: 139051-27-7

Molecular Weight: 903.06

Formula: C45H74O18

Chemical Name: 2-{[4, 5-dihydroxy-6-(hydroxymethyl)-2-{[7, 9, 13-trimethyl-6-(3-methyl-4-{[3, 4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}butyl)-5-oxapentacyclo[10.8.0.0, .0, .0, ]icos-6-en-16-yl]oxy}oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3, 4, 5-triol

Smiles: CC1C2C(CC3C4CCC5CC(CCC5(C)C4CCC32C)OC2OC(CO)C(O)C(O)C2OC2OC(CO)C(O)C(O)C2O)OC=1CCC(C)COC1OC(CO)C(O)C(O)C1O

InChiKey: ROHLIYKWVMBBFX-UHFFFAOYSA-N

InChi: InChI=1S/C45H74O18/c1-19(18-57-41-38(55)35(52)32(49)28(15-46)60-41)5-8-26-20(2)31-27(59-26)14-25-23-7-6-21-13-22(9-11-44(21,3)24(23)10-12-45(25,31)4)58-43-40(37(54)34(51)30(17-48)62-43)63-42-39(56)36(53)33(50)29(16-47)61-42/h19,21-25,27-43,46-56H,5-18H2,1-4H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Kim JY, et al. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food Chem Toxicol. 2009 Jul;47(7):1610-7.
2. Dong J X, Han G Y. A new active steroidal saponin from Anemarrhena asphodeloides[J]. Planta Medica, 1991, 57(05):460-462.

Products are for research use only. Not for human use.