Tyrphostin AG 112

Tyrphostin AG 112 is an EGFR phosphorylation inhibitor.

Product information

CAS Number: 144978-82-5

Molecular Weight: 236.23

Formula: C13H8N4O

Chemical Name: (3Z)-2-amino-3-[(4-hydroxyphenyl)methylidene]prop-1-ene-1, 1, 3-tricarbonitrile

Smiles: NC(=C(C#N)C#N)/C(=C/C1C=CC(O)=CC=1)/C#N

InChiKey: DXVJRTIPBNBLLB-BJMVGYQFSA-N

InChi: InChI=1S/C13H8N4O/c14-6-10(13(17)11(7-15)8-16)5-9-1-3-12(18)4-2-9/h1-5,18H,17H2/b10-5+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Alzahrani AJ. Simultaneous detection of hepatitis C virus core antigen and antibodies in Saudi drug users using a novel assay. J Med Virol. 2008 Apr;80(4):603-6. doi: 10.1002/jmv.21075. PubMed PMID: 18297713.
2. Jeong HY, Son SM, Kim YK, Yun MR, Lee SM, Kim CD. Tyrosine kinase-mediated activation of NADPH oxidase enhances proliferative capacity of diabetic vascular smooth muscle cells. Life Sci. 2005 Feb 25;76(15):1747-57. PubMed PMID: 15698853.
3. Khan AM, Cheung HH, Gillard ER, Palarca JA, Welsbie DS, Gurd JW, Stanley BG. Lateral hypothalamic signaling mechanisms underlying feeding stimulation: differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation. J Neurosci. 2004 Nov 24;24(47):10603-15. PubMed PMID: 15564576.

Products are for research use only. Not for human use.