EGFR-IN-7

EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC50s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity.

Product information

CAS Number: 2267329-76-8

Molecular Weight: 694.60

Formula: C32H41BrN9O2P

Chemical Name: 5-bromo-N4-[5-(dimethylphosphoryl)quinoxalin-6-yl]-N2-{2-methoxy-5-methyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2, 4-diamine

Smiles: CN1CCN(CC1)C1CCN(CC1)C1=CC(OC)=C(C=C1C)NC1=NC(NC2=CC=C3N=CC=NC3=C2P(C)(C)=O)=C(Br)C=N1

InChiKey: ZYSKXRAGBGLELB-UHFFFAOYSA-N

InChi: InChI=1S/C32H41BrN9O2P/c1-21-18-26(28(44-3)19-27(21)42-12-8-22(9-13-42)41-16-14-40(2)15-17-41)38-32-36-20-23(33)31(39-32)37-25-7-6-24-29(35-11-10-34-24)30(25)45(4,5)43/h6-7,10-11,18-20,22H,8-9,12-17H2,1-5H3,(H2,36,37,38,39)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 5 mg/mL (7.20 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Aryl-phosphorus-oxygen compound as egfr kinase inhibitor.

Products are for research use only. Not for human use.