Mytoxin B

Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002 (HY-10108). Mytoxin B induces cell apoptosis via PI3K/Akt pathway.

Product information

CAS Number: 105049-15-8

Molecular Weight: 528.59

Formula: C29H36O9

Chemical Name: Spiro[5, 9:16, 18-dimethano-1H, 3H, 23H-[1, 6, 12]trioxacyclooctadecino[3, 4-d][1]benzopyran-17(18H), 2'-oxirane]-3, 14(9H)-dione, 9-acetyl-6, 7, 10, 11, 16, 16a, 19a, 22-octahydro-25-hydroxy-16a, 21-dimethyl-, (2'S, 4E, 9S, 12Z, 16R, 16aS, 18R, 19aR, 23aR, 25R)- (9CI)

Smiles: C[C@@]12[C@H]3C[C@@H](O[C@@H]4C=C(C)CC[C@]14COC(=O)C=C1CCO[C@](CCC=CC(=O)O3)([C@@H]1O)C(C)=O)[C@]12CO1 |t:19,27|

InChiKey: LXIQXFWXXPJPEE-QZAJVOIVSA-N

InChi: InChI=1S/C29H36O9/c1-17-7-10-27-15-34-24(32)13-19-8-11-35-28(18(2)30,25(19)33)9-5-4-6-23(31)38-20-14-22(37-21(27)12-17)29(16-36-29)26(20,27)3/h4,6,12-13,20-22,25,33H,5,7-11,14-16H2,1-3H3/b6-4-,19-13-/t20-,21-,22-,25-,26-,27-,28+,29+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Huiliang Song, et al. Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway. Molecules. 2019 Jun 20;24(12):2291.

Products are for research use only. Not for human use.