DC41

DC41 is a DC1 derivative. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer.

Product information

CAS Number: 1354787-69-1

Molecular Weight: 680.21

Formula: C37H34ClN5O4S

Chemical Name: N-{2-[(1S)-1-(chloromethyl)-5-hydroxy-1H, 2H, 3H-benzo[e]indole-3-carbonyl]-1H-indol-5-yl}-5-(4-methyl-4-sulfanylpentanamido)-1H-indole-2-carboxamide

Smiles: CC(C)(S)CCC(=O)NC1C=C2C=C(NC2=CC=1)C(=O)NC1C=C2C=C(NC2=CC=1)C(=O)N1C[C@@H](CCl)C2C3=CC=CC=C3C(O)=CC1=2

InChiKey: WVQLZKRXHPZHLA-JOCHJYFZSA-N

InChi: InChI=1S/C37H34ClN5O4S/c1-37(2,48)12-11-33(45)39-23-7-9-27-20(13-23)15-29(41-27)35(46)40-24-8-10-28-21(14-24)16-30(42-28)36(47)43-19-22(18-38)34-26-6-4-3-5-25(26)32(44)17-31(34)43/h3-10,13-17,22,41-42,44,48H,11-12,18-19H2,1-2H3,(H,39,45)(H,40,46)/t22-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
2. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21.

Products are for research use only. Not for human use.