7-MAD-MDCPT

7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).

Product information

CAS Number: 765871-81-6

Molecular Weight: 421.40

Formula: C22H19N3O6

Chemical Name: (5S)-14-(aminomethyl)-5-ethyl-5-hydroxy-7, 18, 20-trioxa-11, 24-diazahexacyclo[11.11.0.0, .0, .0, .0, ]tetracosa-1(24), 2, 4(9), 13, 15, 17(21), 22-heptaene-6, 10-dione

Smiles: CC[C@]1(O)C2C=C3C4=NC5=CC6OCOC=6C=C5C(CN)=C4CN3C(=O)C=2COC1=O

InChiKey: QILNNZJGRYNYJV-QFIPXVFZSA-N

InChi: InChI=1S/C22H19N3O6/c1-2-22(28)14-4-16-19-12(7-25(16)20(26)13(14)8-29-21(22)27)11(6-23)10-3-17-18(31-9-30-17)5-15(10)24-19/h3-5,28H,2,6-9,23H2,1H3/t22-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Jeffrey S, et, al. Camptothecin peptide conjugates. WO2019195665A1.

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