Chicanine

Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity

Product information

CAS Number: 78919-28-5

Molecular Weight: 342.39

Formula: C20H22O5

Chemical Name: 4-[(2R, 3S, 4R, 5R)-5-(2H-1, 3-benzodioxol-5-yl)-3, 4-dimethyloxolan-2-yl]-2-methoxyphenol

Smiles: COC1=CC(=CC=C1O)[C@@H]1O[C@H]([C@H](C)[C@@H]1C)C1=CC=C2OCOC2=C1

InChiKey: JPDORDSJPIKURD-OCBHBYCGSA-N

InChi: InChI=1S/C20H22O5/c1-11-12(2)20(14-5-7-16-18(9-14)24-10-23-16)25-19(11)13-4-6-15(21)17(8-13)22-3/h4-9,11-12,19-21H,10H2,1-3H3/t11-,12+,19+,20+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Chicanine, et al. Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways. Eur J Pharmacol. 2014 Feb 5;724:168-74.

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