AZ-3

AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM.

Product information

CAS Number: 2228908-91-4

Molecular Weight: 385.48

Formula: C20H28FN7

Chemical Name: N4-[(2R)-butan-2-yl]-N2-{2-fluoro-5-[(1S, 4S)-5-methyl-2, 5-diazabicyclo[2.2.1]heptan-2-yl]pyridin-3-yl}-5-methylpyrimidine-2, 4-diamine

Smiles: CN1C[C@@H]2C[C@H]1CN2C1=CN=C(F)C(=C1)NC1=NC(N[C@H](C)CC)=C(C)C=N1

InChiKey: UPSHDXGMMFOWPL-KBMXLJTQSA-N

InChi: InChI=1S/C20H28FN7/c1-5-13(3)24-19-12(2)8-23-20(26-19)25-17-7-14(9-22-18(17)21)28-11-15-6-16(28)10-27(15)4/h7-9,13,15-16H,5-6,10-11H2,1-4H3,(H2,23,24,25,26)/t13-,15+,16+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Grimster NP, et al. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors. J Med Chem. 2018 Jun 28;61(12):5235-5244.

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