Curculigoside

Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway.

Product information

CAS Number: 85643-19-2

Molecular Weight: 466.44

Formula: C22H26O11

Chemical Name: (5-hydroxy-2-{[(2S, 3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl 2, 6-dimethoxybenzoate

Smiles: COC1=CC=CC(OC)=C1C(=O)OCC1=CC(O)=CC=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

InChiKey: SJJRKHVKAXVFJQ-QKYBYQKWSA-N

InChi: InChI=1S/C22H26O11/c1-29-14-4-3-5-15(30-2)17(14)21(28)31-10-11-8-12(24)6-7-13(11)32-22-20(27)19(26)18(25)16(9-23)33-22/h3-8,16,18-20,22-27H,9-10H2,1-2H3/t16-,18-,19+,20-,22-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (214.39 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 µg/ml in MH7A cells. Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group.

References:

1. Tan S, et al. Curculigoside exerts significant anti arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF κB signaling pathway. Mol Med Rep. 2019 Mar;19(3):2057-2064.

Products are for research use only. Not for human use.