Indirubin-3'-monoxime-5-sulphonic acid

Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively.

Product information

CAS Number: 331467-05-1

Molecular Weight: 357.34

Formula: C16H11N3O5S

Chemical Name: (E, 3E)-3-(hydroxyimino)-2'-oxo-1', 2'-dihydro-1H, 3H-[2, 3'-biindolylidene]-5'-sulfonic acid

Smiles: O/N=C1/C(/NC2=CC=CC=C/12)=C1/C2=CC(=CC=C2NC/1=O)S(O)(=O)=O

InChiKey: VUIXUTVIIOVVHV-OIXOFKMYSA-N

InChi: InChI=1S/C16H11N3O5S/c20-16-13(10-7-8(25(22,23)24)5-6-12(10)18-16)15-14(19-21)9-3-1-2-4-11(9)17-15/h1-7,17,21H,(H,18,20)(H,22,23,24)/b15-13+,19-14+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.

Products are for research use only. Not for human use.