1-Azakenpaullone

1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM.

Product information

CAS Number: 676596-65-9

Molecular Weight: 328.16

Formula: C15H10BrN3O

Synonym:

1-Akp

Chemical Name: 14-bromo-3, 8, 18-triazatetracyclo[9.7.0.0, .0, ]octadeca-1(11), 2, 4, 6, 12(17), 13, 15-heptaen-9-one

Smiles: O=C1CC2=C(NC3=CC=C(Br)C=C32)C2=NC=CC=C2N1

InChiKey: NTSBZVCEIVPKBJ-UHFFFAOYSA-N

InChi: InChI=1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 16.67 mg/mL (50.80 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.

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