Azido-PEG4-alcohol

Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 86770-67-4

Molecular Weight: 219.24

Formula: C8H17N3O4

Chemical Name: 2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethan-1-ol

Smiles: [N-]=[N+]=NCCOCCOCCOCCO

InChiKey: MBQYGQMGPFNSAP-UHFFFAOYSA-N

InChi: InChI=1S/C8H17N3O4/c9-11-10-1-3-13-5-7-15-8-6-14-4-2-12/h12H,1-8H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : ≥ 100 mg/mL (456.12 mM) DMSO : ≥ 100 mg/mL (456.12 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

1. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

Products are for research use only. Not for human use.