Thalidomide-5-PEG3-NH2

Thalidomide-5-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

Product information

Molecular Weight: 405.40

Formula: C19H23N3O7

Chemical Name: 5-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-2-(2, 6-dioxopiperidin-3-yl)-2, 3-dihydro-1H-isoindole-1, 3-dione

Smiles: NCCOCCOCCOC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O

InChiKey: XMTFEXSNGIBNRG-UHFFFAOYSA-N

InChi: InChI=1S/C19H23N3O7/c20-5-6-27-7-8-28-9-10-29-12-1-2-13-14(11-12)19(26)22(18(13)25)15-3-4-16(23)21-17(15)24/h1-2,11,15H,3-10,20H2,(H,21,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
2. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-995.

Products are for research use only. Not for human use.