Thalidomide 4-fluoride

Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).

Product information

CAS Number: 835616-60-9

Molecular Weight: 276.22

Formula: C13H9FN2O4

Synonym:

Cereblon ligand 4

E3 ligase Ligand 4

Chemical Name: 2-(2, 6-dioxopiperidin-3-yl)-4-fluoro-2, 3-dihydro-1H-isoindole-1, 3-dione

Smiles: O=C1CCC(C(=O)N1)N1C(=O)C2=C(F)C=CC=C2C1=O

InChiKey: CRAUTELYXAAAPW-UHFFFAOYSA-N

InChi: InChI=1S/C13H9FN2O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5H2,(H,15,17,18)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 200 mg/mL (724.06 mM; Need ultrasonic and warming)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

Products are for research use only. Not for human use.