Taxol Janelia Fluor® 526

Taxol Janelia Fluor® 526 is a fluorogenic, green fluorescent taxol derivative for direct imaging of the microtubule cytoskeleton. Taxol Janelia Fluor® 526 is fluorogenic: it fluoresces only once bound to microtubules, enabling hassle-free no-wash experiments. Excitation maximum = 531 nm; emission maximum = 548 nm.

Product information

CAS Number: 2410613-93-1

Molecular Weight: 1507.40

Formula: C75H75F9N4O19

Synonym:

Janelia Fluor 526-TXL

Chemical Name: 4-((8-(((1S, 2R)-3-(((2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS)-12b-Acetoxy-12-(benzoyloxy)-4, 6, 11-trihydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-2a, 3, 4, 4a, 5, 6, 9, 10, 11, 12, 12a, 12b-dodecahydro-1H-7, 11-methanocyclodeca[3, 4]benzo[1, 2-b]oxet-9-yl)oxy)-2-hydroxy-3-oxo-1-phenylpropyl)amino)-8-oxooctyl)carbamoyl)-2-(3-(3, 3-difluoroazetidin-1-ium-1-ylidene)-6-(3, 3-difluoroazetidin-1-yl)-2, 7-difluoro-3H-xanthen-9-yl)benzoate trifluoroacetate

Smiles: CC1(C)C2[C@@H](O)C(=O)[C@@]3(C)[C@H]([C@H](OC(=O)C4C=CC=CC=4)[C@]1(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)CCCCCCCNC(=O)C1=CC(C4C5=CC(F)=C(C=C5OC5=CC(C(F)=CC5=4)=[N+]4CC(F)(F)C4)N4CC(F)(F)C4)=C(C=C1)C([O-])=O)C1C=CC=CC=1)C=2C)[C@@]1(CO[C@@H]1C[C@@H]3O)OC(C)=O.OC(=O)C(F)(F)F

InChiKey: WYTXGBVNWCQFKK-SOCHEKDQSA-N

InChi: InChI=1S/C73H74F6N4O17.C2HF3O2/c1-37-52(31-73(95)63(99-66(93)40-19-13-10-14-20-40)61-69(5,62(89)59(87)57(37)68(73,3)4)53(85)30-54-72(61,36-96-54)100-38(2)84)98-67(94)60(88)58(39-17-11-9-12-18-39)81-55(86)21-15-7-6-8-16-24-80-64(90)41-22-23-42(65(91)92)43(25-41)56-44-26-46(74)48(82-32-70(76,77)33-82)28-50(44)97-51-29-49(47(75)27-45(51)56)83-34-71(78,79)35-83;3-2(4,5)1(6)7/h9-14,17-20,22-23,25-29,52-54,58-61,63,85,87-88,95H,6-8,15-16,21,24,30-36H2,1-5H3,(H2-,80,81,86,90,91,92);(H,6,7)/t52-,53-,54+,58-,59+,60+,61-,63-,69+,72-,73+;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zheng et al (2019) Rational design of fluorogenic and spontaneously blinking labels for super-resolution imaging. ACS Cent.Sci. 5 1602 PMID: 31572787

Products are for research use only. Not for human use.