Pomalidomide 4'-PEG1-azide

Pomalidomide 4'-PEG1-azide is functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG1 linker with terminal azide ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Product information

CAS Number: 2271036-44-1

Molecular Weight: 386.36

Formula: C17H18N6O5

Synonym:

Pomalidomide-PEG1-C2-N3

Chemical Name: 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2, 6-dioxo-3-piperidinyl)-1H-isoindole-1, 3(2H)-dione

Smiles: [N-]=[N+]=NCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

InChiKey: NJPMWHWTBBYBDY-UHFFFAOYSA-N

InChi: InChI=1S/C17H18N6O5/c18-22-20-7-9-28-8-6-19-11-3-1-2-10-14(11)17(27)23(16(10)26)12-4-5-13(24)21-15(12)25/h1-3,12,19H,4-9H2,(H,21,24,25)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.

Products are for research use only. Not for human use.