JUN76288

JUN76288, also known WEE1-IN-3, is a potent WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases.

Product information

CAS Number: 2272976-28-8

Molecular Weight: 497.59

Formula: C28H31N7O2

Synonym:

WEE1-IN-3

Chemical Name: 6-[(2', 3'-Dihydro-2'-methylspiro[cyclopropane-1, 4'(1'H)-isoquinolin]-7'-yl)amino]-1, 2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-3H-pyrazolo[3, 4-d]pyrimidin-3-one

Smiles: CC(C)(O)C1=CC=CC(=N1)N1C2=NC(NC3=CC4CN(C)CC5(CC5)C=4C=C3)=NC=C2C(=O)N1CC=C

InChiKey: JSZFIXAMFNNRKS-UHFFFAOYSA-N

InChi: InChI=1S/C28H31N7O2/c1-5-13-34-25(36)20-15-29-26(32-24(20)35(34)23-8-6-7-22(31-23)27(2,3)37)30-19-9-10-21-18(14-19)16-33(4)17-28(21)11-12-28/h5-10,14-15,37H,1,11-13,16-17H2,2-4H3,(H,29,30,32)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

JUN76288 inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively. JUN76288 is overexpressed in various cancer types, JUN76288 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ΌΝΑ repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair.

References:

1. Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1.

Products are for research use only. Not for human use.