Antipyrine

Antipyrine, also known as Phenazone, is an analgesic and anti-inflammatory. Antipyrine (AP) metabolism was used to assess factors associated with the activity of hepatic oxidative enzymes in firefighters. The antipyrine test can be used as metabolic probe of biological response to recent dioxin exposure.

Product information

CAS Number: 60-80-0

Molecular Weight: 188.23

Formula: C11H12N2O

Synonym:

Phenazone

Phenazon

Chemical Name: 1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one

Smiles: CN1C(C)=CC(=O)N1C1C=CC=CC=1

InChiKey: VEQOALNAAJBPNY-UHFFFAOYSA-N

InChi: InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (531.26 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Stevenson, I.H., Factors influencing antipyrine elimination. Br J Clin Pharmacol, 1977. 4(3): p. 261-5.
2. Engel G, et, al. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59(6):613-23.

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